Polygenic Score (PGS) ID: PGS002372

Predicted Trait
Reported Trait Monocyte Count
Mapped Trait(s) monocyte count (EFO_0005091)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name blood_MONOCYTE_COUNT.BOLT-LMM-BBJ
Development Method
Name BOLT-LMM-BBJ
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 920,930
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
124,000 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
124,000 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013284 PSS009807|
African Ancestry|
6,119 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Monocyte Count Incremental R2 (full model vs. covariates alone): 0.0059 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013307 PSS009808|
East Asian Ancestry|
894 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Monocyte Count Incremental R2 (full model vs. covariates alone): 0.0379 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013330 PSS009809|
European Ancestry|
41,863 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Monocyte Count Incremental R2 (full model vs. covariates alone): 0.0073 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013353 PSS009810|
South Asian Ancestry|
7,718 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Monocyte Count Incremental R2 (full model vs. covariates alone): 0.0068 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009807 6,119 individuals African unspecified UKB
PSS009808 894 individuals East Asian UKB
PSS009809 41,863 individuals European Non-British European UKB
PSS009810 7,718 individuals South Asian UKB