Polygenic Score (PGS) ID: PGS002380

Predicted Trait
Reported Trait White Blood Count
Mapped Trait(s) leukocyte count (EFO_0004308)
Released in PGS Catalog: June 9, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name blood_WHITE_COUNT.BOLT-LMM-BBJ
Development Method
Name BOLT-LMM-BBJ
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 920,936
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
124,000 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
124,000 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013315 PSS009872|
East Asian Ancestry|
893 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: White Blood Count Incremental R2 (full model vs. covariates alone): 0.0507 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013338 PSS009873|
European Ancestry|
42,026 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: White Blood Count Incremental R2 (full model vs. covariates alone): 0.0029 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013361 PSS009874|
South Asian Ancestry|
7,769 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: White Blood Count Incremental R2 (full model vs. covariates alone): 0.0025 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013292 PSS009871|
African Ancestry|
6,149 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: White Blood Count Incremental R2 (full model vs. covariates alone): 0.0018 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009871 6,149 individuals African unspecified UKB
PSS009872 893 individuals East Asian UKB
PSS009873 42,026 individuals European Non-British European UKB
PSS009874 7,769 individuals South Asian UKB