Polygenic Score (PGS) ID: PGS002385

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name body_BMIz.P+T.0.0001
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 0.0001
Variants
Original Genome Build GRCh37
Number of Variants 15,518
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,394 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 336,394 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013366 PSS009695|
African Ancestry|
6,399 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: BMI — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013415 PSS009696|
East Asian Ancestry|
916 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: BMI — — Incremental R2 (full model vs. covariates alone): 0.0285 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013464 PSS009697|
European Ancestry|
43,328 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: BMI — — Incremental R2 (full model vs. covariates alone): 0.0584 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013513 PSS009698|
South Asian Ancestry|
7,911 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: BMI — — Incremental R2 (full model vs. covariates alone): 0.0341 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009695 — — 6,399 individuals — African unspecified — UKB —
PSS009696 — — 916 individuals — East Asian — UKB —
PSS009697 — — 43,328 individuals — European Non-British European UKB —
PSS009698 — — 7,911 individuals — South Asian — UKB —