Polygenic Score (PGS) ID: PGS002398

Predicted Trait
Reported Trait FEV1/FVC Ratio
Mapped Trait(s) FEV/FEC ratio (EFO_0004713)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name lung_FEV1FVCzSMOKE.P+T.0.0001
Development Method
Name Pruning + Thresholding
Parameters p < 0.0001
Variants
Original Genome Build GRCh37
Number of Variants 12,645
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
274,172 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
274,172 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013379 PSS009747|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: FEV1/FVC Ratio Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013428 PSS009748|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: FEV1/FVC Ratio Incremental R2 (full model vs. covariates alone): 0.0242 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013477 PSS009749|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: FEV1/FVC Ratio Incremental R2 (full model vs. covariates alone): 0.0766 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013526 PSS009750|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: FEV1/FVC Ratio Incremental R2 (full model vs. covariates alone): 0.0316 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009748 679 individuals East Asian UKB
PSS009749 34,753 individuals European Non-British European UKB
PSS009750 5,538 individuals South Asian UKB
PSS009747 4,243 individuals African unspecified UKB