Polygenic Score (PGS) ID: PGS002407

Predicted Trait
Reported Trait Hypertension
Mapped Trait(s) hypertension (EFO_0000537)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name disease_HYPERTENSION_DIAGNOSED.P+T.0.0001
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 0.0001
Variants
Original Genome Build GRCh37
Number of Variants 6,693
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,972 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 336,972 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013388 PSS009783|
African Ancestry|
6,438 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013437 PSS009784|
East Asian Ancestry|
913 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model vs. covariates alone): 0.0023 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013486 PSS009785|
European Ancestry|
43,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model vs. covariates alone): 0.0185 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013535 PSS009786|
South Asian Ancestry|
7,948 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model vs. covariates alone): 0.012 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009783 — — 6,438 individuals — African unspecified — UKB —
PSS009784 — — 913 individuals — East Asian — UKB —
PSS009785 — — 43,392 individuals — European Non-British European UKB —
PSS009786 — — 7,948 individuals — South Asian — UKB —