Polygenic Score (PGS) ID: PGS002410

Predicted Trait
Reported Trait Lymphocyte count
Mapped Trait(s) lymphocyte count (EFO_0004587)
Released in PGS Catalog: June 9, 2022
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name blood_LYMPHOCYTE_COUNT.P+T.0.0001
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 0.0001
Variants
Original Genome Build GRCh37
Number of Variants 14,889
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
326,304 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 326,304 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013391 PSS009795|
African Ancestry|
6,135 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013440 PSS009796|
East Asian Ancestry|
895 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0566 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013489 PSS009797|
European Ancestry|
41,973 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0706 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013538 PSS009798|
South Asian Ancestry|
7,737 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0387 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM039157 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.01037 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009795 — — 6,135 individuals — African unspecified — UKB —
PSS009796 — — 895 individuals — East Asian — UKB —
PSS009797 — — 41,973 individuals — European Non-British European UKB —
PSS009798 — — 7,737 individuals — South Asian — UKB —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —