Polygenic Score (PGS) ID: PGS002410

Predicted Trait
Reported Trait Lymphocyte Count
Mapped Trait(s) lymphocyte count (EFO_0004587)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name blood_LYMPHOCYTE_COUNT.P+T.0.0001
Development Method
Name Pruning + Thresholding
Parameters p < 0.0001
Variants
Original Genome Build GRCh37
Number of Variants 14,889
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
326,304 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
326,304 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013391 PSS009795|
African Ancestry|
6,135 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Lymphocyte Count Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013440 PSS009796|
East Asian Ancestry|
895 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Lymphocyte Count Incremental R2 (full model vs. covariates alone): 0.0566 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013489 PSS009797|
European Ancestry|
41,973 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Lymphocyte Count Incremental R2 (full model vs. covariates alone): 0.0706 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013538 PSS009798|
South Asian Ancestry|
7,737 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Lymphocyte Count Incremental R2 (full model vs. covariates alone): 0.0387 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009796 895 individuals East Asian UKB
PSS009797 41,973 individuals European Non-British European UKB
PSS009798 7,737 individuals South Asian UKB
PSS009795 6,135 individuals African unspecified UKB