Polygenic Score (PGS) ID: PGS002439

Predicted Trait
Reported Trait Chronotype (morning person)
Mapped Trait(s) chronotype measurement (EFO_0008328)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name other_MORNINGPERSON.P+T.0.001
Development Method
Name Pruning + Thresholding
Parameters p < 0.001
Variants
Original Genome Build GRCh37
Number of Variants 16,590
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
301,397 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
301,397 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013616 PSS009716|
East Asian Ancestry|
827 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Chronotype (morning person) Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013567 PSS009715|
African Ancestry|
5,524 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Chronotype (morning person) Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013665 PSS009717|
European Ancestry|
39,178 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Chronotype (morning person) Incremental R2 (full model vs. covariates alone): 0.004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013714 PSS009718|
South Asian Ancestry|
6,975 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Chronotype (morning person) Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009716 827 individuals East Asian UKB
PSS009717 39,178 individuals European Non-British European UKB
PSS009718 6,975 individuals South Asian UKB
PSS009715 5,524 individuals African unspecified UKB