Polygenic Score (PGS) ID: PGS002444

Predicted Trait
Reported Trait Eczema
Mapped Trait(s) Eczema (HP_0000964)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.001
Development Method
Name Pruning + Thresholding
Parameters p < 0.001
Variants
Original Genome Build GRCh37
Number of Variants 16,802
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
337,071 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
337,071 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013572 PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013621 PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013670 PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0036 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013719 PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009735 6,423 individuals African unspecified UKB
PSS009736 905 individuals East Asian UKB
PSS009737 43,398 individuals European Non-British European UKB
PSS009738 7,942 individuals South Asian UKB