Polygenic Score (PGS) ID: PGS002464

Predicted Trait
Reported Trait Platelet count
Mapped Trait(s) platelet count (EFO_0004309)
Released in PGS Catalog: June 9, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name blood_PLATELET_COUNT.P+T.0.001
Development Method
Name Pruning + Thresholding
Parameters p < 0.001
Variants
Original Genome Build GRCh37
Number of Variants 54,318
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
326,621 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
326,621 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013592 PSS009815|
African Ancestry|
6,143 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.0009 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013641 PSS009816|
East Asian Ancestry|
895 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.0596 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013690 PSS009817|
European Ancestry|
42,007 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.1455 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013739 PSS009818|
South Asian Ancestry|
7,730 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Platelet count Incremental R2 (full model vs. covariates alone): 0.0778 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009815 6,143 individuals African unspecified UKB
PSS009816 895 individuals East Asian UKB
PSS009817 42,007 individuals European Non-British European UKB
PSS009818 7,730 individuals South Asian UKB