Polygenic Score (PGS) ID: PGS002474

Predicted Trait
Reported Trait Triglycerides
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name biochemistry_Triglycerides.P+T.0.001
Development Method
Name Pruning + Thresholding
Parameters p < 0.001
Variants
Original Genome Build GRCh37
Number of Variants 27,130
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
319,244 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
319,244 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013602 PSS009855|
African Ancestry|
6,066 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Triglycerides Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013651 PSS009856|
East Asian Ancestry|
868 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Triglycerides Incremental R2 (full model vs. covariates alone): 0.0225 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013700 PSS009857|
European Ancestry|
40,890 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Triglycerides Incremental R2 (full model vs. covariates alone): 0.0405 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013749 PSS009858|
South Asian Ancestry|
7,553 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Triglycerides Incremental R2 (full model vs. covariates alone): 0.0301 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009855 6,066 individuals African unspecified UKB
PSS009856 868 individuals East Asian UKB
PSS009857 40,890 individuals European Non-British European UKB
PSS009858 7,553 individuals South Asian UKB