Polygenic Score (PGS) ID: PGS002477

Predicted Trait
Reported Trait Waist-Hip Ratio
Mapped Trait(s) waist-hip ratio (EFO_0004343)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name body_WHRadjBMIz.P+T.0.001
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 0.001
Variants
Original Genome Build GRCh37
Number of Variants 27,033
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,847 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
336,847 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013605 PSS009867|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Waist-Hip Ratio Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013654 PSS009868|
East Asian Ancestry|
917 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Waist-Hip Ratio Incremental R2 (full model vs. covariates alone): 0.0067 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013703 PSS009869|
European Ancestry|
43,384 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Waist-Hip Ratio Incremental R2 (full model vs. covariates alone): 0.0413 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013752 PSS009870|
South Asian Ancestry|
8,026 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Waist-Hip Ratio Incremental R2 (full model vs. covariates alone): 0.0164 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009868 917 individuals East Asian UKB
PSS009869 43,384 individuals European Non-British European UKB
PSS009870 8,026 individuals South Asian UKB
PSS009867 6,423 individuals African unspecified UKB