Polygenic Score (PGS) ID: PGS002508

Predicted Trait
Reported Trait Lymphocyte count
Mapped Trait(s) lymphocyte count (EFO_0004587)
Released in PGS Catalog: June 9, 2022
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name blood_LYMPHOCYTE_COUNT.P+T.0.01
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 0.01
Variants
Original Genome Build GRCh37
Number of Variants 140,957
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
326,304 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 326,304 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013881 PSS009797|
European Ancestry|
41,973 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0456 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013783 PSS009795|
African Ancestry|
6,135 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013832 PSS009796|
East Asian Ancestry|
895 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0123 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013930 PSS009798|
South Asian Ancestry|
7,737 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Lymphocyte Count — — Incremental R2 (full model vs. covariates alone): 0.0138 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM038815 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.0482 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009795 — — 6,135 individuals — African unspecified — UKB —
PSS009796 — — 895 individuals — East Asian — UKB —
PSS009797 — — 41,973 individuals — European Non-British European UKB —
PSS009798 — — 7,737 individuals — South Asian — UKB —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —