Polygenic Score (PGS) ID: PGS002546

Predicted Trait
Reported Trait Forced Vital Capacity
Mapped Trait(s) vital capacity (EFO_0004312)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name lung_FVCzSMOKE.P+T.1e-06
Development Method
Name Pruning + Thresholding
Parameters p < 1e-06
Variants
Original Genome Build GRCh37
Number of Variants 2,327
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
274,172 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
274,172 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013968 PSS009751|
African Ancestry|
4,243 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.006 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014017 PSS009752|
East Asian Ancestry|
679 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0154 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014066 PSS009753|
European Ancestry|
34,753 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0241 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014115 PSS009754|
South Asian Ancestry|
5,538 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Forced Vital Capacity Incremental R2 (full model vs. covariates alone): 0.0168 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009751 4,243 individuals African unspecified UKB
PSS009752 679 individuals East Asian UKB
PSS009753 34,753 individuals European Non-British European UKB
PSS009754 5,538 individuals South Asian UKB