Polygenic Score (PGS) ID: PGS002549

Predicted Trait
Reported Trait Hair Color
Mapped Trait(s) hair colour measurement (EFO_0007822)
Released in PGS Catalog: June 9, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name pigment_HAIR.P+T.1e-06
Development Method
Name Pruning + Thresholding
Parameters p < 1e-06
Variants
Original Genome Build GRCh37
Number of Variants 10,216
Effect Weight Type BETA
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
332,641 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
332,641 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013971 PSS009763|
African Ancestry|
6,421 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hair Color Incremental R2 (full model vs. covariates alone): 0.0073 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014020 PSS009764|
East Asian Ancestry|
916 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hair Color Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014069 PSS009765|
European Ancestry|
42,940 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hair Color Incremental R2 (full model vs. covariates alone): 0.1828 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014118 PSS009766|
South Asian Ancestry|
7,961 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Hair Color Incremental R2 (full model vs. covariates alone): 0.014 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009764 916 individuals East Asian UKB
PSS009765 42,940 individuals European Non-British European UKB
PSS009766 7,961 individuals South Asian UKB
PSS009763 6,421 individuals African unspecified UKB