Polygenic Score (PGS) ID: PGS002596

Predicted Trait
Reported Trait Glucose
Mapped Trait(s) glucose measurement (EFO_0004468)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name biochemistry_Glucose.P+T.5e-08
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 5e-08
Variants
Original Genome Build GRCh37
Number of Variants 482
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
291,275 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 291,275 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014165 PSS009755|
African Ancestry|
5,505 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014214 PSS009756|
East Asian Ancestry|
794 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014263 PSS009757|
European Ancestry|
37,281 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.0038 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014312 PSS009758|
South Asian Ancestry|
6,744 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Glucose — — Incremental R2 (full model vs. covariates alone): 0.0011 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009756 — — 794 individuals — East Asian — UKB —
PSS009757 — — 37,281 individuals — European Non-British European UKB —
PSS009758 — — 6,744 individuals — South Asian — UKB —
PSS009755 — — 5,505 individuals — African unspecified — UKB —