Polygenic Score (PGS) ID: PGS002610

Predicted Trait
Reported Trait Neuroticism
Mapped Trait(s) neuroticism measurement (EFO_0007660)
Released in PGS Catalog: June 9, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name mental_NEUROTICISM.P+T.5e-08
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 5e-08
Variants
Original Genome Build GRCh37
Number of Variants 196
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
274,316 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
274,316 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014179 PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0012 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014228 PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0079 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014326 PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0018 age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014277 PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009812 603 individuals East Asian UKB
PSS009813 34,276 individuals European Non-British European UKB
PSS009814 4,984 individuals South Asian UKB
PSS009811 4,454 individuals African unspecified UKB