Polygenic Score (PGS) ID: PGS002630

Predicted Trait
Reported Trait BMI
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name body_BMIz.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 620,484
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,394 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
336,394 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014346 PSS009695|
African Ancestry|
6,399 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMI Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0345 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_BMIz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014395 PSS009696|
East Asian Ancestry|
916 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMI Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0624 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_BMIz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014444 PSS009697|
European Ancestry|
43,328 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMI Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1307 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_BMIz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014493 PSS009698|
South Asian Ancestry|
7,911 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMI Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0832 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_BMIz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009695 6,399 individuals African unspecified UKB
PSS009696 916 individuals East Asian UKB
PSS009697 43,328 individuals European Non-British European UKB
PSS009698 7,911 individuals South Asian UKB