Polygenic Score (PGS) ID: PGS002643

Predicted Trait
Reported Trait FEV1/FVC ratio
Mapped Trait(s) FEV/FVC ratio (EFO_0004713)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name lung_FEV1FVCzSMOKE.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 508,629
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
274,172 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 274,172 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014408 PSS009748|
East Asian Ancestry|
679 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0481 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014359 PSS009747|
African Ancestry|
4,243 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0403 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014457 PSS009749|
European Ancestry|
34,753 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1362 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014506 PSS009750|
South Asian Ancestry|
5,538 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: FEV1/FVC Ratio — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0736 age, sex, age*sex, assessment center, genotyping array, 10 PCs See lung_FEV1FVCzSMOKE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009748 — — 679 individuals — East Asian — UKB —
PSS009749 — — 34,753 individuals — European Non-British European UKB —
PSS009750 — — 5,538 individuals — South Asian — UKB —
PSS009747 — — 4,243 individuals — African unspecified — UKB —