Polygenic Score (PGS) ID: PGS002663

Predicted Trait
Reported Trait Red blood cell distribution width
Mapped Trait(s) Red cell distribution width (EFO_0009188)
Additional Trait Information Red Blood Cell Dist. Width
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name blood_RBC_DISTRIB_WIDTH.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 340,172
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
325,395 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 325,395 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014379 PSS009827|
African Ancestry|
5,990 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Red Blood Cell Distribution Width — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0343 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_RBC_DISTRIB_WIDTH.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014428 PSS009828|
East Asian Ancestry|
888 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Red Blood Cell Distribution Width — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1048 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_RBC_DISTRIB_WIDTH.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014477 PSS009829|
European Ancestry|
41,837 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Red Blood Cell Distribution Width — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1682 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_RBC_DISTRIB_WIDTH.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014526 PSS009830|
South Asian Ancestry|
7,623 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Red Blood Cell Distribution Width — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1097 age, sex, age*sex, assessment center, genotyping array, 10 PCs See blood_RBC_DISTRIB_WIDTH.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009828 — — 888 individuals — East Asian — UKB —
PSS009829 — — 41,837 individuals — European Non-British European UKB —
PSS009830 — — 7,623 individuals — South Asian — UKB —
PSS009827 — — 5,990 individuals — African unspecified — UKB —