Polygenic Score (PGS) ID: PGS002688

Predicted Trait
Reported Trait Diastolic blood pressure
Mapped Trait(s) diastolic blood pressure (EFO_0006336)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name bp_DIASTOLICadjMEDz.SBayesR
Development Method
Name SBayesR
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 985,844
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
310,831 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 310,831 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014600 PSS009732|
East Asian Ancestry|
859 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diastolic blood pressure — — Incremental R2 (full model vs. covariates alone): 0.089 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014551 PSS009731|
African Ancestry|
6,128 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diastolic blood pressure — — Incremental R2 (full model vs. covariates alone): 0.0195 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014649 PSS009733|
European Ancestry|
40,059 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diastolic blood pressure — — Incremental R2 (full model vs. covariates alone): 0.1072 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014698 PSS009734|
South Asian Ancestry|
7,573 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diastolic blood pressure — — Incremental R2 (full model vs. covariates alone): 0.0596 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009732 — — 859 individuals — East Asian — UKB —
PSS009733 — — 40,059 individuals — European Non-British European UKB —
PSS009734 — — 7,573 individuals — South Asian — UKB —
PSS009731 — — 6,128 individuals — African unspecified — UKB —