Polygenic Score (PGS) ID: PGS002726

Predicted Trait
Reported Trait Multiple sclerosis
Mapped Trait(s) multiple sclerosis (MONDO_0005301)
Released in PGS Catalog: June 29, 2022
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Score Details

Score Construction
PGS Name PGS_MS_Brain
Development Method
Name Genome-wide significant variants
Parameters NR
Original Genome Build GRCh37
Number of Variants 476,399
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000334
Citation (link to publication) Shams H et al. Brain (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
41,505 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
  • 14,802 cases
  • , 26,703 controls
European IMSGC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014749 PSS009883|
European Ancestry|
253,419 individuals
PGP000334 |
Shams H et al. Brain (2022)
Reported Trait: Multiple sclerosis AUROC: 0.73 [0.72, 0.74] Odds ratio (OR, top 10% vs median): 5.3 [4.7, 6.0]
PPM014750 PSS009882|
European Ancestry|
938 individuals
PGP000334 |
Shams H et al. Brain (2022)
Reported Trait: Multiple sclerosis AUROC: 0.8 [0.76, 0.82] Odds ratio (OR, top 10% vs median): 15.0 [10.4, 24.0]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 433 cases
  • , 505 controls
European KP
  • 1,354 cases
  • , 252,065 controls
European UKB