| Predicted Trait | |
| Reported Trait | Knee osteoarthritis |
| Mapped Trait(s) | osteoarthritis, knee (EFO_0004616) |
| Score Construction | |
| PGS Name | PRS_knee |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | p<1.3E–8 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 24 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000336 |
| Citation (link to publication) | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 98.9% East Asian: 1.1% 396,044 individuals (100%) |
| PGS Evaluation | European: 100% 3 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST90034523 Europe PMC: 34450027 |
391,749 individuals | European | 9 cohorts
|
GWAS Catalog: GCST90034523 Europe PMC: 34450027 |
4,295 individuals | East Asian | 9 cohorts
|
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM014760 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent radiographic osteoarthritis | OR: 1.17 [1.1, 1.24] | — | — | — | — |
| PPM014771 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident clinical osteoarthritis | OR: 1.26 [1.05, 1.52] | — | — | — | — |
| PPM014793 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Clinical osteoarthritis | — | AUROC: 0.6 [0.55, 0.65] | — | Age, sex, BMI | — |
| PPM014761 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident radiographic osteoarthritis | OR: 1.15 [1.06, 1.24] | — | — | — | — |
| PPM014762 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent radiographic osteoarthritis | OR: 1.27 [0.96, 1.68] | — | — | — | — |
| PPM014763 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident radiographic osteoarthritis | OR: 1.09 [0.93, 1.29] | — | — | — | — |
| PPM014764 | PSS009890| European Ancestry| 407 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent radiographic osteoarthritis | OR: 1.02 [0.69, 1.53] | — | — | — | — |
| PPM014765 | PSS009890| European Ancestry| 407 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident radiographic osteoarthritis | OR: 1.04 [0.75, 1.45] | — | — | — | — |
| PPM014769 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent clinical osteoarthritis | OR: 1.23 [1.12, 1.34] | — | — | — | — |
| PPM014770 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident clinical osteoarthritis | OR: 1.13 [0.94, 1.37] | — | — | — | — |
| PPM014772 | PSS009890| European Ancestry| 407 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident clinical osteoarthritis | OR: 1.17 [0.8, 1.73] | — | — | — | — |
| PPM014776 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Prevalent total knee replacement | OR: 1.3 [0.99, 1.71] | — | — | — | — |
| PPM014777 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident total knee replacement | OR: 1.56 [1.27, 1.91] | — | — | — | — |
| PPM014778 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident total knee replacement | OR: 1.16 [0.65, 2.17] | — | — | — | — |
| PPM014780 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Radiographic osteoarthritis progression | OR: 1.18 [1.11, 1.25] | — | — | — | — |
| PPM014782 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Incident severe radiographic osteoarthritis | OR: 1.3 [1.04, 1.63] | — | — | — | — |
| PPM014789 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Radiographic osteoarthritis | — | AUROC: 0.6 [0.58, 0.63] | — | Age, sex, BMI | — |
| PPM014790 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Radiographic osteoarthritis | — | AUROC: 0.57 [0.53, 0.62] | — | Age, sex, BMI | — |
| PPM014791 | PSS009890| European Ancestry| 407 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Radiographic osteoarthritis | — | AUROC: 0.53 [0.44, 0.63] | — | Age, BMI | — |
| PPM014792 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Clinical osteoarthritis | — | AUROC: 0.66 [0.61, 0.71] | — | Age, sex, BMI | — |
| PPM014794 | PSS009890| European Ancestry| 407 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Clinical osteoarthritis | — | AUROC: 0.52 [0.41, 0.63] | — | Age, BMI | — |
| PPM014795 | PSS009891| European Ancestry| 14,926 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Total hip replacement | — | AUROC: 0.66 [0.61, 0.71] | — | Age, sex, BMI | — |
| PPM014796 | PSS009889| European Ancestry| 1,002 individuals |
PGP000336 | Sedaghati-Khayat B et al. Arthritis Rheumatol (2022) |
Reported Trait: Total hip replacement | — | AUROC: 0.65 [0.49, 0.82] | — | Age, sex, BMI | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009889 | Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both joints.In the CHECK cohort, clinical OA was defined as clinically relevant hip or knee osteoarthritis by a group of 36 GPs and secondary care physicians by manually evaluating the study records over the 5-10 years of follow-up | — | 1,002 individuals, 21.0 % Male samples |
Mean = 55.9 years Sd = 5.2 years |
European | — | NR | CHECK |
| PSS009890 | Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both joints.Clinical OA in the PROOF cohort was defined based on the American College of Rheumatology (ACR) definition [26], which is defined based on knee pain on most days of the last month plus at least 3 of the following clinical findings: age > 50 years, stiffness < 30 minutes, crepitus, bony tenderness, bony enlargement, and no palpable warmth. Prevalent cases were defined at baseline. | — | 407 individuals, 0.0 % Male samples |
Mean = 55.8 years Sd = 3.2 years |
European | — | NR | PROOF |
| PSS009891 | Radiographic hip and/or knee-OA was defined in all five cohorts by a KL score ≥ 2 for one or both joints.Clinical OA in Rotterdam Study was defined as reported pain in the last month and a KL score ≥ 2 in that hip or knee joint and the control group was defined as containing all participants who had not been diagnosed with radiographic OA by the end of follow-up time. | — | 14,926 individuals | — | European | — | RS | — |