Polygenic Score (PGS) ID: PGS002730

Predicted Trait
Reported Trait LDL lowering in response to statin
Mapped Trait(s)
Released in PGS Catalog: June 29, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRSlipid_35
Development Method
Name Genome-wide significant variants
Parameters p<1E-05, r2<0.001
Variants
Original Genome Build NR
Number of Variants 35
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000337
Citation (link to publication) Mayerhofer E et al. Brain (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
18,596 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002675
Europe PMC: 25350695
 18,596 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014797 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: On-statin LDL decrease β: -0.05 [-0.07, -0.02] — — — —
PPM014798 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: Incident intracerebral hemorrhage HR: 1.16 [1.05, 1.28] — — — —
PPM014799 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: Incident myocardial infarction HR: 0.98 [0.96, 0.99] — — — —
PPM014800 PSS009892|
European Ancestry|
75,973 individuals
 PGP000337 |
Mayerhofer E et al. Brain (2022)
 Reported Trait: Incident Peripheral Artery Disease HR: 0.93 [0.87, 0.99] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009892 — — 75,973 individuals,
57.2 % Male samples
 Mean = 60.4 years
Sd = 6.6 years		 European — UKB —