Polygenic Score (PGS) ID: PGS002731

Predicted Trait
Reported Trait Alzheimer's disease
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: June 29, 2022
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Score Details

Score Construction
PGS Name oA-PRS
Development Method
Name Variants associated with Alzheimer’s disease
Parameters MAF >1%
Variants
Original Genome Build hg19
Number of Variants 17
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000339
Citation (link to publication) Xicota L et al. Neurology (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 100%
Score Development/Training
Not Reported: 100%
291 individuals (100%)
PGS Evaluation
Not Reported: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 31863938
 NR Not reported NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 291 individuals,
38.8 % Male samples
 Not reported NR — Mean = 76.4 years
Sd = 3.5 years		 — — INSIGHT

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014809 PSS009897|
Ancestry Not Reported|
228 individuals
 PGP000339 |
Xicota L et al. Neurology (2022)
 Reported Trait: Amyloid burden OR: 3.38 [1.02, 11.63] — — — —
PPM014810 PSS009897|
Ancestry Not Reported|
228 individuals
 PGP000339 |
Xicota L et al. Neurology (2022)
 Reported Trait: Amyloid burden in E4 carriers OR: 44.94 [3.03, 1277.0] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009897 — — 228 individuals,
49.6 % Male samples
 Mean = 76.62 years
Sd = 4.55 years		 Not reported — ADNI —