Polygenic Score (PGS) ID: PGS002733

Predicted Trait
Reported Trait Type 2 diabetes (T2D)
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: July 21, 2022
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Score Details

Score Construction
PGS Name GRS17_T2D
Development Method
Name Genome-wide significant variants
Parameters OR ≥1.10, effect allele frequency ≥10%
Variants
Original Genome Build GRCh37
Number of Variants 17
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000342
Citation (link to publication) Pezzilli S et al. Diabetes Metab (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
159,208 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004773
Europe PMC: 28566273
 159,208 individuals European DIAGRAM

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014821 PSS009902|
European Ancestry|
600 individuals
 PGP000342 |
Pezzilli S et al. Diabetes Metab (2022)
 Reported Trait: Early-onset type 2 diabetes OR: 1.09 [1.01, 1.18] — — — —
PPM014822 PSS009902|
European Ancestry|
600 individuals
 PGP000342 |
Pezzilli S et al. Diabetes Metab (2022)
 Reported Trait: Early-onset type 2 diabetes in rare variant carriers OR: 1.45 [1.15, 1.57] — — — —
PPM014823 PSS009902|
European Ancestry|
600 individuals
 PGP000342 |
Pezzilli S et al. Diabetes Metab (2022)
 Reported Trait: Early-onset type 2 diabetes in rare variant non-carriers OR: 1.06 [1.01, 1.13] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009902 — —
[
  • 300 cases
  • , 300 controls
]
 — European
(Italian)		 — NR —