Polygenic Score (PGS) ID: PGS002738

Predicted Trait
Reported Trait Alcohol use disorder
Mapped Trait(s) alcohol dependence (MONDO_0007079)
Released in PGS Catalog: Aug. 3, 2022
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Score Details

Score Construction
PGS Name PRS_AUD
Development Method
Name PRS-CS
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 326,000
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000345
Citation (link to publication) Lai D et al. Alcohol Clin Exp Res (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 81.7%
African: 14.3%
Hispanic or Latin American: 3.6%
East Asian: 0.3%
South Asian: 0.05%
395,995 individuals (100%)
PGS Evaluation
European: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008259
Europe PMC: 30940813
202,004 individuals European MVP
GWAS Catalog: GCST008259
Europe PMC: 30940813
56,648 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST008259
Europe PMC: 30940813
14,175 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST008259
Europe PMC: 30940813
1,374 individuals East Asian MVP
GWAS Catalog: GCST008259
Europe PMC: 30940813
190 individuals South Asian MVP
GWAS Catalog: GCST006717
Europe PMC: 30336701
121,604 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014839 PSS009910|
European Ancestry|
2,722 individuals
PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
Reported Trait: Alcohol use disorder (AUD) in individuals with unknown family history of AUD β: 2.91 (0.38) Odds Ratio (OR top 10% vs rest): 1.5 [0.98, 2.29]
PPM014840 PSS009908|
European Ancestry|
336 individuals
PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
Reported Trait: Alcohol use disorder (AUD) in individuals without family history of AUD β: 2.64 (0.47) Odds Ratio (OR top 10% vs rest): 0.45 [0.12, 1.69]
PPM014841 PSS009911|
European Ancestry|
7,900 individuals
PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
Reported Trait: Alcohol use disorder β: 3.17 (1.87) Odds Ratio (OR top 10% vs rest): 1.96 [1.54, 2.51]
PPM014838 PSS009909|
European Ancestry|
4,842 individuals
PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
Reported Trait: Alcohol use disorder (AUD) in individuals with family history of AUD β: 2.43 (0.6) Odds Ratio (OR top 10% vs rest): 1.86 [1.35, 2.56]

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009909
[
  • 2,531 cases
  • , 669 controls
]
European COGA
PSS009910
[
  • 850 cases
  • , 840 controls
]
European COGA
PSS009911
[
  • 3,451 cases
  • , 1,616 controls
]
,
48.0 % Male samples
European COGA
PSS009908
[
  • 72 cases
  • , 107 controls
]
European COGA