Polygenic Score (PGS) ID: PGS002746

Predicted Trait
Reported Trait Attention-deficit hyperactivity disorder
Mapped Trait(s) attention deficit hyperactivity disorder (EFO_0003888)
Released in PGS Catalog: Sept. 8, 2022
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Score Details

Score Construction
PGS Name PRS_ADHD
Development Method
Name Genome-wide significant variants
Parameters r2>0.1, p<0.05
Variants
Original Genome Build NR
Number of Variants 513,659
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000358
Citation (link to publication) Lahey BB et al. J Psychiatr Res (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 96.2%
East Asian: 3.5%
Not Reported: 0.3%
55,374 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007543
Europe PMC: 30478444
144 individuals Not reported NR
GWAS Catalog: GCST007543
Europe PMC: 30478444
53,293 individuals European NR
GWAS Catalog: GCST007543
Europe PMC: 30478444
1,937 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014920 PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Specific internalizing (at baseline) β: -0.06 (0.02)
PPM014921 PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Specific conduct problem (1-year follow-up) β: 0.09 (0.02)
PPM014922 PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Specific ADHD (1-year follow-up) β: 0.11 (0.03)
PPM014924 PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: UPPS Impulsive Behavior Scale (Positive urgency) β: 0.046 (0.016) Age, sex, and the first 10 principal components of population structure
PPM014925 PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Latent executive functioning β: -0.042 Age, sex, and the first 10 principal components of population structure
PPM014919 PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: General factor of psychological problems (1-year follow-up) β: 0.07 (0.02)
PPM014923 PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: UPPS Impulsive Behavior Scale (Low perseverance) β: 0.043 (0.017) Age, sex, and the first 10 principal components of population structure

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009931 4,483 individuals,
53.2 % Male samples
Mean = 118.94 months
Sd = 7.48 months
European NR ABCD