Polygenic Score (PGS) ID: PGS002755

Predicted Trait
Reported Trait Atopic dermatitis
Mapped Trait(s) atopic eczema (EFO_0000274)
Released in PGS Catalog: Nov. 7, 2022
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Score Details

Score Construction
PGS Name Atopic_dermatitis_prscs
Development Method
Name PRS-CS
Parameters PRS-CS-auto in FinnGen, LD reference panel: European ancestry in 1000 Genomes
Variants
Original Genome Build GRCh38
Number of Variants 1,090,702
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000364
Citation (link to publication) Mars N et al. Am J Hum Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 88.2%
East Asian: 8.1%
Hispanic or Latin American: 1.6%
African: 1.1%
Not Reported: 1%
116,863 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST003184
Europe PMC: 26482879
 103,066 individuals European NR
GWAS Catalog: GCST003184
Europe PMC: 26482879
 1,892 individuals Hispanic or Latin American NR
GWAS Catalog: GCST003184
Europe PMC: 26482879
 1,266 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST003184
Europe PMC: 26482879
 9,438 individuals East Asian NR
GWAS Catalog: GCST003184
Europe PMC: 26482879
 1,201 individuals Not reported NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014955 PSS009939|
European Ancestry|
39,444 individuals
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Reported Trait: Atopic dermatitis OR: 1.28 [1.21, 1.34] — — age, sex, 10 PCs, technical covariates —
PPM020709 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
|Ext.		 Reported Trait: Incident atopic dermatitis — — Hazard ratio (HR, high vs low PRS): 1.249 [1.123, 1.391] sex, age, Townsend index, moderate physical and household income —
PPM020710 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
|Ext.		 Reported Trait: Incident atopic dermatitis with air pollution level — — Hazard ratio (HR, high air pollution and high PRS vs low air pollution and low PRS): 1.978 [1.624, 2.411] sex, age, Townsend index, moderate physical and household income —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009939 — — 39,444 individuals — European
(Finnish)		 — FinnGen —
PSS011376 — Median = 12.0 years 337,910 individuals,
45.6 % Male samples
 Mean = 57.1 years
Sd = 8.0 years		 European — UKB —