Polygenic Score (PGS) ID: PGS002762

Predicted Trait
Reported Trait Gout
Mapped Trait(s) gout (EFO_0004274)
Additional Trait Information PGS for urate
Released in PGS Catalog: Nov. 7, 2022
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Score Details

Score Construction
PGS Name Urate_prscs
Development Method
Name PRS-CS
Parameters PRS-CS-auto in FinnGen, LD reference panel: European ancestry in 1000 Genomes
Variants
Original Genome Build GRCh38
Number of Variants 1,092,214
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000364
Citation (link to publication) Mars N et al. Am J Hum Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 63.1%
East Asian: 27.5%
African: 7.4%
South Asian: 2%
Hispanic or Latin American: 0.1%
457,690 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008972
Europe PMC: 31578528
 288,649 individuals European NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 33,671 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 9,037 individuals South Asian NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 608 individuals Hispanic or Latin American NR
GWAS Catalog: GCST008972
Europe PMC: 31578528
 125,725 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014962 PSS009939|
European Ancestry|
39,444 individuals
 PGP000364 |
Mars N et al. Am J Hum Genet (2022)
 Reported Trait: Gout OR: 1.69 [1.6, 1.78] — — age, sex, 10 PCs, technical covariates —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009939 — — 39,444 individuals — European
(Finnish)		 — FinnGen —