PGS Catalog - PGS002785 / Schizophrenia (Polygenic Score)

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
Europe PMC: 29906448	65,967 individuals [ 33,426 cases , 32,541 controls ]	European	PGC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM015033	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (total problems)	—	—	partial R²: 0.00016	age, PCs1-3	—
PPM015034	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 depression)	—	—	partial R²: 0.00116	age, PCs1-3	—
PPM014992	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (anxious/depressed)	—	—	partial R²: 0.00015	age, PCs1-3	—
PPM015043	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Picture vocabulary)	—	—	partial R²: 0.00024	age, PCs1-3	—
PPM015364	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Corticospinal tract R	—	—	partial R²: 0.00123	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015035	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 anxety disorder)	—	—	partial R²: 0.00024	age, PCs1-3	—
PPM015036	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 somatic problem)	—	—	partial R²: 0.00025	age, PCs1-3	—
PPM015037	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 adhd)	—	—	partial R²: 0.00011	age, PCs1-3	—
PPM015038	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 opppsit)	—	—	partial R²: 0.00012	age, PCs1-3	—
PPM015039	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 conduct)	—	—	partial R²: 6.77e-06	age, PCs1-3	—
PPM015040	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Sluggish cognitive tempo)	—	—	partial R²: 0.0019	age, PCs1-3	—
PPM014993	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (withdrawn)	—	—	partial R²: 0.00085	age, PCs1-3	—
PPM014994	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (somatic symptoms)	—	—	partial R²: 4.36e-07	age, PCs1-3	—
PPM014995	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (social problems)	—	—	partial R²: 0.00032	age, PCs1-3	—
PPM014996	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (thought problems)	—	—	partial R²: 0.00093	age, PCs1-3	—
PPM014997	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (attention problems)	—	—	partial R²: 0.00041	age, PCs1-3	—
PPM014998	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (rule breaking)	—	—	partial R²: 0.00028	age, PCs1-3	—
PPM014999	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (aggressive behaviour)	—	—	partial R²: 0.00048	age, PCs1-3	—
PPM015000	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (internalising)	—	—	partial R²: 0.00026	age, PCs1-3	—
PPM015001	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (externalising)	—	—	partial R²: 0.00046	age, PCs1-3	—
PPM015002	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (total problems)	—	—	partial R²: 0.00056	age, PCs1-3	—
PPM015003	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 depression)	—	—	partial R²: 0.00089	age, PCs1-3	—
PPM015005	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 somatic problem)	—	—	partial R²: 0.00021	age, PCs1-3	—
PPM015006	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 adhd)	—	—	partial R²: 0.00081	age, PCs1-3	—
PPM015007	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 opppsit)	—	—	partial R²: 0.00021	age, PCs1-3	—
PPM015008	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 conduct)	—	—	partial R²: 0.00039	age, PCs1-3	—
PPM015009	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Sluggish cognitive tempo)	—	—	partial R²: 0.00038	age, PCs1-3	—
PPM015010	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Obsessive compulsive disorder)	—	—	partial R²: 8e-05	age, PCs1-3	—
PPM015011	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (stress)	—	—	partial R²: 0.00088	age, PCs1-3	—
PPM015013	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Flanker test)	—	—	partial R²: 0.00179	age, PCs1-3	—
PPM015014	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (list sorting)	—	—	partial R²: 0.00287	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015015	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (card sorting)	—	—	partial R²: 0.0039	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015016	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (pattern comparison)	—	—	partial R²: 0.00279	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015017	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Picture sequence)	—	—	partial R²: 0.00062	age, PCs1-3	—
PPM015018	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (reading)	—	—	partial R²: 0.0027	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015019	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (fluid composite)	—	—	partial R²: 0.00502	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015020	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Crystallized composite)	—	—	partial R²: 0.00661	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015021	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Cognitive total)	—	—	partial R²: 0.00806	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015022	PSS009953\| European Ancestry\| 68,614 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (fluid composite)	—	—	partial R²: 0.00398	age, PCs1-10	the observed partial R² were higher than random R²s
PPM015023	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (anxious/depressed)	—	—	partial R²: 8e-05	age, PCs1-3	—
PPM015024	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (withdrawn)	—	—	partial R²: 4.06e-06	age, PCs1-3	—
PPM015025	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (somatic symptoms)	—	—	partial R²: 0.00087	age, PCs1-3	—
PPM015026	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (social problems)	—	—	partial R²: 7e-05	age, PCs1-3	—
PPM015027	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (thought problems)	—	—	partial R²: 0.00053	age, PCs1-3	—
PPM015044	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Flanker test)	—	—	partial R²: 0.00017	age, PCs1-3	—
PPM015045	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (list sorting)	—	—	partial R²: 0.00411	age, PCs1-3	—
PPM015046	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (card sorting)	—	—	partial R²: 0.00034	age, PCs1-3	—
PPM015047	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (pattern comparison)	—	—	partial R²: 0.00019	age, PCs1-3	—
PPM015048	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Picture sequence)	—	—	partial R²: 0.00024	age, PCs1-3	—
PPM015049	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (reading)	—	—	partial R²: 0.0001	age, PCs1-3	—
PPM015050	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (fluid composite)	—	—	partial R²: 0.00146	age, PCs1-3	—
PPM015051	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Crystallized composite)	—	—	partial R²: 4e-05	age, PCs1-3	—
PPM015052	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Cognitive total)	—	—	partial R²: 0.00082	age, PCs1-3	—
PPM015365	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_61	—	—	partial R²: 0.00131	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015366	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_103	—	—	partial R²: 0.00146	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015367	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_109	—	—	partial R²: 0.00191	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015368	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_130	—	—	partial R²: 0.00179	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015369	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_132	—	—	partial R²: 0.00116	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015370	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_149	—	—	partial R²: 0.00186	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015371	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_184	—	—	partial R²: 0.00137	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015372	PSS009954\| European Ancestry\| 11,180 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_185	—	—	partial R²: 0.00234	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015373	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cingulate gyrus anterior division right	—	—	partial R²: 0.00074	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015374	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Middle cerebellar peduncle	—	—	partial R²: 0.00076	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015375	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Superior cerebellar peduncle R	—	—	partial R²: 0.00097	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015376	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Superior cerebellar peduncle L	—	—	partial R²: 0.00085	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015377	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cerebral peduncle R	—	—	partial R²: 0.00101	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015378	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Retrolenticular part of internal capsule R	—	—	partial R²: 0.00097	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015379	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: External capsule R	—	—	partial R²: 0.00074	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015380	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cingulum (cingulate gyrus) R	—	—	partial R²: 0.00121	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015381	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cingulum (cingulate gyrus) L	—	—	partial R²: 0.0008	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015382	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Superior longitudinal fasciculus R	—	—	partial R²: 0.00107	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015383	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Superior longitudinal fasciculus L	—	—	partial R²: 0.00105	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015384	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Superior fronto-occipital fasciculus R	—	—	partial R²: 0.00085	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015385	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cingulum (cingulate gyrus) R	—	—	partial R²: 0.00137	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015386	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Inferior fronto-occipital fasciculus R	—	—	partial R²: 0.00072	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015387	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_11	—	—	partial R²: 0.00121	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015388	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_16	—	—	partial R²: 0.00091	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015389	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_24	—	—	partial R²: 0.00139	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015390	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_36	—	—	partial R²: 0.00078	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015391	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_55	—	—	partial R²: 0.0009	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015392	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_66	—	—	partial R²: 0.00094	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015393	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_68	—	—	partial R²: 0.00095	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015395	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_83	—	—	partial R²: 0.00119	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015396	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_90	—	—	partial R²: 0.00092	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015397	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_91	—	—	partial R²: 0.00087	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015398	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_123	—	—	partial R²: 0.00084	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015399	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_136	—	—	partial R²: 0.00072	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015400	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_137	—	—	partial R²: 0.0009	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015401	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_142	—	—	partial R²: 0.00098	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015402	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_161	—	—	partial R²: 0.00098	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015403	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_175	—	—	partial R²: 0.00071	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015404	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_189	—	—	partial R²: 0.00126	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015405	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_191	—	—	partial R²: 0.0033	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015406	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_199	—	—	partial R²: 0.00085	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015028	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (attention problems)	—	—	partial R²: 0.00043	age, PCs1-3	—
PPM015029	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (rule breaking)	—	—	partial R²: 8e-05	age, PCs1-3	—
PPM015030	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (aggressive behaviour)	—	—	partial R²: 2e-05	age, PCs1-3	—
PPM015031	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (internalising)	—	—	partial R²: 0.00023	age, PCs1-3	—
PPM015032	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (externalising)	—	—	partial R²: 3e-05	age, PCs1-3	—
PPM015041	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Obsessive compulsive disorder)	—	—	partial R²: 1.46e-06	age, PCs1-3	—
PPM015004	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (Dsm5 anxety disorder)	—	—	partial R²: 6e-05	age, PCs1-3	—
PPM015012	PSS009950\| European Ancestry\| 2,524 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (Picture vocabulary)	—	—	partial R²: 0.00682	age, PCs1-3	the observed partial R² were higher than random R²s
PPM015042	PSS009949\| European Ancestry\| 2,198 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Psychiatric behavior (stress)	—	—	partial R²: 0.00038	age, PCs1-3	—
PPM015053	PSS009951\| European Ancestry\| 78,561 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: Cognitive function (fluid composite)	—	—	partial R²: 0.00399	age, PCs1-10	the observed partial R² were higher than random R²s
PPM015394	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_69	—	—	partial R²: 0.00078	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s
PPM015407	PSS009952\| European Ancestry\| 10,343 individuals	PGP000370 \| Gui Y et al. Transl Psychiatry (2022)	Reported Trait: ICA component_206	—	—	partial R²: 0.00124	age, headsize scaling factor, PCs1-10	the observed partial R² were higher than random R²s

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS009949	NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously.	—	2,198 individuals, 0.0 % Male samples	Mean = 9.89 years Sd = 0.61 years	European	—	ABCD	—
PSS009950	NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously.	—	2,524 individuals, 100.0 % Male samples	Mean = 9.92 years Sd = 0.62 years	European	—	ABCD	—
PSS009951	Fluid intelligence test	—	78,561 individuals, 0.0 % Male samples	Mean = 57.46 years Sd = 8.08 years	European	—	UKB	—
PSS009952	imaging-derived phenotypes (IDPs) generated by an image-processing pipeline developed and ran on behalf of the UKB	—	10,343 individuals, 0.0 % Male samples	Mean = 63.13 years Sd = 7.3 years	European	—	UKB	—
PSS009953	Fluid intelligence test	—	68,614 individuals, 100.0 % Male samples	Mean = 58.39 years Sd = 8.36 years	European	—	UKB	—
PSS009954	imaging-derived phenotypes (IDPs) generated by an image-processing pipeline developed and ran on behalf of the UKB	—	11,180 individuals, 100.0 % Male samples	Mean = 64.6 years Sd = 7.57 years	European	—	UKB	—

Predicted Trait
Reported Trait	Schizophrenia
Mapped Trait(s)	schizophrenia (MONDO_0005090)

Score Construction
PGS Name	SCZ_SDPR
Development Method
Name	SDPR
Parameters	used hapmap3 SNPs from genotype in 1000G as the reference panel, MAF>0.05
Variants
Original Genome Build	hg19
Number of Variants	964,422
Effect Weight Type	beta

PGS Source
PGS Catalog Publication (PGP) ID	PGP000370
Citation (link to publication)	Gui Y et al. Transl Psychiatry (2022)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 100% 65,967 individuals (100%)
PGS Evaluation	European: 100% 6 Sample Sets

Polygenic Score (PGS) ID: PGS002785

Score Details

Development Samples

Source of Variant Associations (GWAS)

Performance Metrics

Evaluated Samples