Polygenic Score (PGS) ID: PGS002788

Predicted Trait
Reported Trait Type 2 bipolar disorder
Mapped Trait(s) bipolar II disorder (EFO_0009964)
Released in PGS Catalog: Sept. 29, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name BD2_SDPR
Development Method
Name SDPR
Parameters used hapmap3 SNPs from genotype in 1000G as the reference panel, MAF>0.05
Variants
Original Genome Build hg19
Number of Variants 935,292
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000370
Citation (link to publication) Gui Y et al. Transl Psychiatry (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
34,779 individuals (100%)
PGS Evaluation
European: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008116
Europe PMC: 31043756
 34,779 individuals European PGC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015179 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 3e-05 age, PCs1-3 —
PPM015180 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00065 age, PCs1-3 —
PPM015181 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00039 age, PCs1-3 —
PPM015182 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00024 age, PCs1-3 —
PPM015183 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.00092 age, PCs1-3 —
PPM015185 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00217 age, PCs1-3 —
PPM015186 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00055 age, PCs1-3 —
PPM015187 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00192 age, PCs1-3 —
PPM015188 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00114 age, PCs1-3 —
PPM015189 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 2.60e-06 age, PCs1-3 —
PPM015190 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00045 age, PCs1-3 —
PPM015191 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00071 age, PCs1-3 —
PPM015192 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.0006 age, PCs1-3 —
PPM015193 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00195 age, PCs1-3 —
PPM015194 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00088 age, PCs1-3 —
PPM015196 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00097 age, PCs1-3 —
PPM015197 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00138 age, PCs1-3 —
PPM015198 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00049 age, PCs1-3 —
PPM015199 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00024 age, PCs1-3 —
PPM015200 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00036 age, PCs1-3 —
PPM015201 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.00014 age, PCs1-3 —
PPM015202 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 6e-05 age, PCs1-3 —
PPM015203 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00011 age, PCs1-3 —
PPM015204 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 1e-05 age, PCs1-3 —
PPM015205 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.0003 age, PCs1-3 —
PPM015206 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 6e-05 age, PCs1-3 —
PPM015207 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00026 age, PCs1-3 —
PPM015209 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00163 age, PCs1-3 —
PPM015210 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00156 age, PCs1-3 —
PPM015211 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00085 age, PCs1-3 —
PPM015212 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00123 age, PCs1-3 —
PPM015213 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 8e-05 age, PCs1-3 —
PPM015214 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 3e-05 age, PCs1-3 —
PPM015215 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00057 age, PCs1-3 —
PPM015216 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 5e-05 age, PCs1-3 —
PPM015217 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00197 age, PCs1-3 —
PPM015218 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00016 age, PCs1-3 —
PPM015220 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.0006 age, PCs1-3 —
PPM015221 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00145 age, PCs1-3 —
PPM015222 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00071 age, PCs1-3 —
PPM015223 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 3e-05 age, PCs1-3 —
PPM015224 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 3e-05 age, PCs1-3 —
PPM015225 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 4e-05 age, PCs1-3 —
PPM015226 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.0001 age, PCs1-3 —
PPM015227 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00125 age, PCs1-3 —
PPM015228 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00025 age, PCs1-3 —
PPM015230 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 1.91e-06 age, PCs1-3 —
PPM015231 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 3.47e-06 age, PCs1-3 —
PPM015232 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 8.67e-06 age, PCs1-3 —
PPM015233 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 9.91e-06 age, PCs1-3 —
PPM015234 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 7e-05 age, PCs1-3 —
PPM015235 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.0001 age, PCs1-3 —
PPM015236 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 3e-05 age, PCs1-3 —
PPM015237 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 7e-05 age, PCs1-3 —
PPM015238 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 3.27e-06 age, PCs1-3 —
PPM015239 PSS009951|
European Ancestry|
78,561 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 5.36e-06 age, PCs1-10 —
PPM015178 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00052 age, PCs1-3 —
PPM015184 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00084 age, PCs1-3 —
PPM015195 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00307 age, PCs1-3 —
PPM015208 PSS009953|
European Ancestry|
68,614 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 9.85e-06 age, PCs1-10 —
PPM015219 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00068 age, PCs1-3 —
PPM015229 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00035 age, PCs1-3 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009949 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,198 individuals,
0.0 % Male samples
 Mean = 9.89 years
Sd = 0.61 years		 European — ABCD —
PSS009950 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,524 individuals,
100.0 % Male samples
 Mean = 9.92 years
Sd = 0.62 years		 European — ABCD —
PSS009951 Fluid intelligence test — 78,561 individuals,
0.0 % Male samples
 Mean = 57.46 years
Sd = 8.08 years		 European — UKB —
PSS009953 Fluid intelligence test — 68,614 individuals,
100.0 % Male samples
 Mean = 58.39 years
Sd = 8.36 years		 European — UKB —