Polygenic Score (PGS) ID: PGS002789

Predicted Trait
Reported Trait Major depressive disorder
Mapped Trait(s) major depressive disorder (MONDO_0002009)
Released in PGS Catalog: Sept. 29, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name MDD_SDPR
Development Method
Name SDPR
Parameters used hapmap3 SNPs from genotype in 1000G as the reference panel, MAF>0.05
Variants
Original Genome Build hg19
Number of Variants 943,784
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000370
Citation (link to publication) Gui Y et al. Transl Psychiatry (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
480,359 individuals (100%)
PGS Evaluation
European: 100%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005839
Europe PMC: 29700475
 480,359 individuals European 23andMe, GS:SFHS, PGC, deCODE, iPSYCH

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015246 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00268 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015300 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00106 age, PCs1-3 —
PPM015241 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00533 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015242 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00626 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015243 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00358 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015244 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00276 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015247 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00203 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015248 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00815 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015249 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00246 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015250 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00528 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015251 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00752 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015252 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00657 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015253 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00516 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015254 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.00088 age, PCs1-3 —
PPM015255 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00172 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015256 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00205 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015257 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.0067 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015258 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00297 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015259 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00464 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015260 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00077 age, PCs1-3 —
PPM015261 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 7e-05 age, PCs1-3 —
PPM015262 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00112 age, PCs1-3 —
PPM015263 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.00064 age, PCs1-3 —
PPM015264 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 0.00012 age, PCs1-3 —
PPM015265 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00045 age, PCs1-3 —
PPM015266 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.00281 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015267 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00047 age, PCs1-3 —
PPM015268 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 0.00222 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015269 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00155 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015270 PSS009953|
European Ancestry|
68,614 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00137 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015271 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00213 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015272 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00201 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015273 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00469 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015274 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00414 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015275 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00322 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015276 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.00218 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015277 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00165 age, PCs1-3 —
PPM015279 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00397 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015280 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00439 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015281 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00566 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015282 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00515 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015283 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00335 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015284 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00266 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015285 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.00154 age, PCs1-3 —
PPM015286 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00642 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015287 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00155 age, PCs1-3 —
PPM015288 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00254 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015289 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00049 age, PCs1-3 —
PPM015290 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.0055 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015291 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00143 age, PCs1-3 —
PPM015292 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00019 age, PCs1-3 —
PPM015293 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00068 age, PCs1-3 —
PPM015294 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 6e-05 age, PCs1-3 —
PPM015295 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 5e-05 age, PCs1-3 —
PPM015296 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00048 age, PCs1-3 —
PPM015297 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.00014 age, PCs1-3 —
PPM015301 PSS009951|
European Ancestry|
78,561 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00137 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015422 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Genu of corpus callosum — — partial R²: 0.00139 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015423 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Body of corpus callosum — — partial R²: 0.00095 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015424 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior limb of internal capsule R — — partial R²: 0.00161 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015425 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior limb of internal capsule L — — partial R²: 0.00093 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015426 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Posterior limb of internal capsule R — — partial R²: 0.0008 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015427 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior corona radiata R — — partial R²: 0.00087 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015428 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior corona radiata L — — partial R²: 0.00092 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015429 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cingulum cingulate gyrus R — — partial R²: 0.00105 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015430 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior frontooccipital fasciculus R — — partial R²: 0.00096 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015431 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Genu of corpus callosum — — partial R²: 0.00106 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015432 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Body of corpus callosum — — partial R²: 0.00123 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015433 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior limb of internal capsule R — — partial R²: 0.00155 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015434 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior corona radiata R — — partial R²: 0.00097 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015435 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior corona radiata L — — partial R²: 0.00097 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015436 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior corona radiata R — — partial R²: 0.00146 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015437 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior corona radiata L — — partial R²: 0.00099 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015438 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior longitudinal fasciculus R — — partial R²: 0.00094 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015439 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior longitudinal fasciculus L — — partial R²: 0.00109 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015440 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior frontooccipital fasciculus R — — partial R²: 0.00081 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015441 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Anterior thalamic radiation right — — partial R²: 0.00102 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015442 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Forceps minor — — partial R²: 0.00115 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015443 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior longitudinal fasciculus L — — partial R²: 0.00099 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015444 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Superior thalamic radiation R — — partial R²: 0.00131 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015445 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_83 — — partial R²: 0.00079 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015446 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_104 — — partial R²: 0.00119 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015447 PSS009952|
European Ancestry|
10,343 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: ICA component_202 — — partial R²: 0.00058 age, headsize scaling factor, PCs1-10 the observed partial R² were higher than random R²s
PPM015240 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00486 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015245 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.00211 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015278 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00498 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015298 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00067 age, PCs1-3 —
PPM015299 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 0.00088 age, PCs1-3 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009949 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,198 individuals,
0.0 % Male samples
 Mean = 9.89 years
Sd = 0.61 years		 European — ABCD —
PSS009950 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,524 individuals,
100.0 % Male samples
 Mean = 9.92 years
Sd = 0.62 years		 European — ABCD —
PSS009951 Fluid intelligence test — 78,561 individuals,
0.0 % Male samples
 Mean = 57.46 years
Sd = 8.08 years		 European — UKB —
PSS009952 imaging-derived phenotypes (IDPs) generated by an image-processing pipeline developed and ran on behalf of the UKB — 10,343 individuals,
0.0 % Male samples
 Mean = 63.13 years
Sd = 7.3 years		 European — UKB —
PSS009953 Fluid intelligence test — 68,614 individuals,
100.0 % Male samples
 Mean = 58.39 years
Sd = 8.36 years		 European — UKB —