Polygenic Score (PGS) ID: PGS002790

Predicted Trait
Reported Trait Autism spectrum disorder
Mapped Trait(s) autism spectrum disorder (EFO_0003756)
Released in PGS Catalog: Sept. 29, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name ASD_SDPR
Development Method
Name SDPR
Parameters used hapmap3 SNPs from genotype in 1000G as the reference panel, MAF>0.05
Variants
Original Genome Build hg19
Number of Variants 916,713
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000370
Citation (link to publication) Gui Y et al. Transl Psychiatry (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
46,350 individuals (100%)
PGS Evaluation
European: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007556
Europe PMC: 30804558
 46,350 individuals European PGC, iPSYCH

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015302 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 4.69e-07 age, PCs1-3 —
PPM015363 PSS009951|
European Ancestry|
78,561 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00176 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015303 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00125 age, PCs1-3 —
PPM015304 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00061 age, PCs1-3 —
PPM015305 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00012 age, PCs1-3 —
PPM015306 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00063 age, PCs1-3 —
PPM015307 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.0025 age, PCs1-3 —
PPM015308 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.0002 age, PCs1-3 —
PPM015309 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00071 age, PCs1-3 —
PPM015310 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00037 age, PCs1-3 —
PPM015311 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00059 age, PCs1-3 —
PPM015313 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00043 age, PCs1-3 —
PPM015314 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 1.74e-06 age, PCs1-3 —
PPM015315 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00075 age, PCs1-3 —
PPM015316 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.00167 age, PCs1-3 —
PPM015317 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00068 age, PCs1-3 —
PPM015318 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00049 age, PCs1-3 —
PPM015319 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.0033 age, PCs1-3 —
PPM015320 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00017 age, PCs1-3 —
PPM015321 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00052 age, PCs1-3 —
PPM015323 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00024 age, PCs1-3 —
PPM015324 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00119 age, PCs1-3 —
PPM015325 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 0.00056 age, PCs1-3 —
PPM015326 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 0.00012 age, PCs1-3 —
PPM015327 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00063 age, PCs1-3 —
PPM015328 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.0005 age, PCs1-3 —
PPM015329 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 4e-05 age, PCs1-3 —
PPM015330 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 0.0013 age, PCs1-3 —
PPM015331 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00017 age, PCs1-3 —
PPM015333 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (anxious/depressed) — — partial R²: 0.00313 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015334 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (withdrawn) — — partial R²: 0.00546 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015335 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (somatic symptoms) — — partial R²: 0.00032 age, PCs1-3 —
PPM015336 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (social problems) — — partial R²: 0.00287 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015337 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (thought problems) — — partial R²: 0.00221 age, PCs1-3 —
PPM015338 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (attention problems) — — partial R²: 0.00377 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015339 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (rule breaking) — — partial R²: 0.00135 age, PCs1-3 —
PPM015340 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (aggressive behaviour) — — partial R²: 0.00138 age, PCs1-3 —
PPM015341 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (internalising) — — partial R²: 0.00344 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015342 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (externalising) — — partial R²: 0.00156 age, PCs1-3 —
PPM015343 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00382 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015344 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 depression) — — partial R²: 0.00429 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015345 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 anxety disorder) — — partial R²: 0.00227 age, PCs1-3 —
PPM015346 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 somatic problem) — — partial R²: 0.00025 age, PCs1-3 —
PPM015347 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 adhd) — — partial R²: 0.00296 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015348 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 opppsit) — — partial R²: 0.00205 age, PCs1-3 —
PPM015349 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Dsm5 conduct) — — partial R²: 0.00133 age, PCs1-3 —
PPM015350 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Sluggish cognitive tempo) — — partial R²: 0.00422 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015352 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (stress) — — partial R²: 0.00239 age, PCs1-3 —
PPM015353 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 1e-05 age, PCs1-3 —
PPM015354 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Flanker test) — — partial R²: 0.00035 age, PCs1-3 —
PPM015355 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (list sorting) — — partial R²: 0.00075 age, PCs1-3 —
PPM015356 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (card sorting) — — partial R²: 8e-05 age, PCs1-3 —
PPM015357 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (pattern comparison) — — partial R²: 2.82e-07 age, PCs1-3 —
PPM015358 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture sequence) — — partial R²: 0.00121 age, PCs1-3 —
PPM015359 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (reading) — — partial R²: 0.00013 age, PCs1-3 —
PPM015360 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00021 age, PCs1-3 —
PPM015361 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Crystallized composite) — — partial R²: 6e-05 age, PCs1-3 —
PPM015312 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (total problems) — — partial R²: 0.00075 age, PCs1-3 —
PPM015322 PSS009950|
European Ancestry|
2,524 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Picture vocabulary) — — partial R²: 0.00168 age, PCs1-3 —
PPM015332 PSS009953|
European Ancestry|
68,614 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (fluid composite) — — partial R²: 0.00026 age, PCs1-10 the observed partial R² were higher than random R²s
PPM015351 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Psychiatric behavior (Obsessive compulsive disorder) — — partial R²: 0.00258 age, PCs1-3 the observed partial R² were higher than random R²s
PPM015362 PSS009949|
European Ancestry|
2,198 individuals
 PGP000370 |
Gui Y et al. Transl Psychiatry (2022)
 Reported Trait: Cognitive function (Cognitive total) — — partial R²: 0.00021 age, PCs1-3 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009949 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,198 individuals,
0.0 % Male samples
 Mean = 9.89 years
Sd = 0.61 years		 European — ABCD —
PSS009950 NIH Toolbox was used to measure cognition in ABCD. Children’s problems and competencies were rated using the parent-reported Children Behavior Checklist (CBCL). Details of the ABCD MRI data acquisition and analysis have been published previously. — 2,524 individuals,
100.0 % Male samples
 Mean = 9.92 years
Sd = 0.62 years		 European — ABCD —
PSS009951 Fluid intelligence test — 78,561 individuals,
0.0 % Male samples
 Mean = 57.46 years
Sd = 8.08 years		 European — UKB —
PSS009953 Fluid intelligence test — 68,614 individuals,
100.0 % Male samples
 Mean = 58.39 years
Sd = 8.36 years		 European — UKB —