Polygenic Score (PGS) ID: PGS002808

Predicted Trait
Reported Trait Lung cancer
Mapped Trait(s) lung carcinoma (EFO_0001071)
Released in PGS Catalog: Nov. 7, 2022
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Score Details

Score Construction
PGS Name PGS20_LC
Development Method
Name Genome-wide significant SNPs
Parameters p<1.9E-03
Variants
Original Genome Build GRCh37
Number of Variants 20
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000387
Citation (link to publication) Qin N et al. Lancet Oncol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
85,716 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004748
Europe PMC: 2860473
 85,716 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015574 PSS009988|
European Ancestry|
450,821 individuals
 PGP000387 |
Qin N et al. Lancet Oncol (2022)
 Reported Trait: Lung cancer — — Hazard ratio (HR, high vs low risk): 1.48 [1.31, 1.68] — —
PPM015576 PSS009988|
European Ancestry|
450,821 individuals
 PGP000387 |
Qin N et al. Lancet Oncol (2022)
 Reported Trait: Lung cancer x autosomal mosaic loss abnormalities interaction HR: 1.95 [1.02, 3.7] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009988 — —
[
  • 2,088 cases
  • , 448,733 controls
]
,
46.0 % Male samples
 — European — UKB —