Polygenic Score (PGS) ID: PGS002809

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Nov. 7, 2022
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Score Details

Score Construction
PGS Name GRS_CAD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 205
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000388
Citation (link to publication) Ahmed R et al. Int J Cardiol Heart Vasc (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 38.6%
  • European
  • South Asian
European: 31.3%
Not Reported: 20.2%
East Asian: 10%
2,202,086 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005194
Europe PMC: 29212778
 296,525 individuals NR UKB
GWAS Catalog: GCST010479
Europe PMC: 32469254
 51,442 individuals East Asian NR
GWAS Catalog: GCST010479
Europe PMC: 32469254
 340,799 individuals East Asian, European NR
Europe PMC: 28584231
[
  • 71,263 cases
  • , 76,535 controls
]
 Not reported NR
Europe PMC: 28209224
[
  • 42,335 cases
  • , 78,240 controls
]
 European NR
GWAS Catalog: GCST000998
Europe PMC: 21378990
 86,995 individuals European 12 cohorts
  • ADVANCE
  • ,AtheroRemo
  • ,CADomics
  • ,CHARGE
  • ,GerMIFS
  • ,LURIC
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PennCATH
  • ,WTCCC
  • ,deCODE_CAD
Europe PMC: 23202125
[
  • 63,746 cases
  • , 130,681 controls
]
 European, South Asian NR
GWAS Catalog: GCST010866
Europe PMC: 33020668
 480,830 individuals European NR
GWAS Catalog: GCST010866
Europe PMC: 33020668
 168,228 individuals East Asian NR
Europe PMC: 28530674
[
  • 88,192 cases
  • , 162,544 controls
]
 European, South Asian, East Asian, African American or Afro-Caribbean NR
GWAS Catalog: GCST004787
Europe PMC: 28714975
 63,731 individuals European, NR NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015577 PSS009989|
European Ancestry|
360,098 individuals
 PGP000388 |
Ahmed R et al. Int J Cardiol Heart Vasc (2022)
 Reported Trait: Incident coronary artery disease — — Hazard ratio (HR, >=3 vs <0.5 risk): 3.02 [2.73, 3.33] — Calculated as Population‐standardized GRS
PPM015578 PSS009989|
European Ancestry|
360,098 individuals
 PGP000388 |
Ahmed R et al. Int J Cardiol Heart Vasc (2022)
 Reported Trait: Incident coronary artery disease in subjects with borderline-/intermediate-ASCVD risk — — Hazard ratio (HR, >=3 vs <0.5 risk): 2.91 [2.59, 3.26] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009989 — — 360,098 individuals,
45.1 % Male samples
 Mean = 56.95 years European — UKB —