Polygenic Score (PGS) ID: PGS003258

Predicted Trait
Reported Trait Estimated glomerular filtration rate (Creatine)
Mapped Trait(s)
Additional Trait Information eGFRcrea; Quantitative
Released in PGS Catalog: Nov. 23, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name ExPRSweb_Creatine_eGFRcrea-overall-EA_PRSCS_MGI_20211120
Development Method
Parameters PRS-CS (auto)_traiteGFR_prefixeGFRcrea_overall_EA.
Original Genome Build GRCh37
Number of Variants 16,682
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000393
Citation (link to publication) Ma Y et al. Am J Hum Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
111,666 individuals (100%)
Score Development/Training
European: 100%
20,396 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
111,666 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
20,396 individuals European MGI CREATININE LEVEL (LOINC: 2160-0); Quantitative

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015713 PSS009999|
European Ancestry|
20,396 individuals
PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
Reported Trait: Creatine β: -0.0157 (0.00141) : 0.00487 SEX,AGE,Batch,PC1,PC2,PC3,PC4

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009999 CREATININE LEVEL (LOINC: 2160-0); Quantitative 20,396 individuals European MGI