Polygenic Score (PGS) ID: PGS003329

Predicted Trait
Reported Trait Gout
Mapped Trait(s) gout (EFO_0004274)
Released in PGS Catalog: Nov. 23, 2022
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Score Details

Score Construction
PGS Name PRS19_gout
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08
Variants
Original Genome Build GRCh37
Number of Variants 19
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000394
Citation (link to publication) Sumpter NA et al. Arthritis Rheumatol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
332,370 individuals (100%)
PGS Evaluation
Additional Diverse Ancestries: 66.7%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 7,131 cases
  • , 325,239 controls
]
 European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016117 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in men) β: -3.61 [-4.32, -2.9] — — 10 Global PCs —
PPM016120 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in men) β: 1.15 [1.0, 1.31] — — 10 Global PCs —
PPM016123 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in women) β: 0.07 [-2.32, 2.45] — — 10 Global PCs —
PPM016126 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in women) β: 0.68 [0.42, 1.1] — — 10 Global PCs —
PPM016119 PSS010040|
Additional Diverse Ancestries|
869 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in men) β: -3.51 [-5.46, -1.57] — — 10 Global PCs + 10 Oceanian PCs —
PPM016121 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in men) β: 2.6 [1.66, 4.06] — — 10 Global PCs + 10 Oceanian PCs —
PPM016122 PSS010040|
Additional Diverse Ancestries|
869 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in men) β: 1.53 [1.07, 2.19] — — 10 Global PCs + 10 Oceanian PCs —
PPM016124 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in women) β: 0.2 [-7.21, 7.62] — — 10 Global PCs + 10 Oceanian PCs —
PPM016125 PSS010040|
Additional Diverse Ancestries|
869 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in women) β: -3.33 [-9.28, 2.62] — — 10 Global PCs + 10 Oceanian PCs —
PPM016127 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in women) β: 1.45 [0.39, 5.36] — — 10 Global PCs + 10 Oceanian PCs —
PPM016118 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in men) β: -6.35 [-8.91, -3.8] — — 10 Global PCs + 10 Oceanian PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010038 — —
[
  • 682 cases
  • , 704 controls
]
 — Oceanian Aotearoa NZ Maori and Cook Island Maori ancestry NR East Polynesian
PSS010039 — —
[
  • 4,016 cases
  • , 1,506 controls
]
 — European — CLEAR Australia and Aotearoa New Zealand cohort, GlobalGout, LASSO, CRYSTAL, LIGHT
PSS010040 — —
[
  • 490 cases
  • , 379 controls
]
 — Oceanian Samoan, Tongan, Niuean, Tokelauan and Pukapukan NR West Polynesian