Polygenic Score (PGS) ID: PGS003330

Predicted Trait
Reported Trait Factor VIII levels
Mapped Trait(s) factor VIII measurement (EFO_0004630)
Released in PGS Catalog: Nov. 23, 2022
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Score Details

Score Construction
PGS Name PRS-F8
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 10
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000395
Citation (link to publication) Valenti L et al. JHEP Rep (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 79.4%
African: 13.8%
Hispanic or Latin American: 4.4%
Multi-ancestry (excluding European): 2.4%
  • South Asian
  • East Asian
32,610 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007445
Europe PMC: 30586737
 773 individuals South Asian,East Asian NR
GWAS Catalog: GCST007445
Europe PMC: 30586737
 1,440 individuals Hispanic or Latin American NR
GWAS Catalog: GCST007445
Europe PMC: 30586737
 25,897 individuals European NR
GWAS Catalog: GCST007445
Europe PMC: 30586737
 4,500 individuals African American or Afro-Caribbean NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016128 PSS010041|
European Ancestry|
581 individuals
 PGP000395 |
Valenti L et al. JHEP Rep (2022)
 Reported Trait: von Willebrand factor β: 152.57 (14.24) — — — —
PPM016129 PSS010041|
European Ancestry|
581 individuals
 PGP000395 |
Valenti L et al. JHEP Rep (2022)
 Reported Trait: Factor VIII levels β: 92.45 (10.2) — — — —
PPM016130 PSS010041|
European Ancestry|
581 individuals
 PGP000395 |
Valenti L et al. JHEP Rep (2022)
 Reported Trait: Factor VIII/protein ratio β: 0.88 (0.11) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010041 — — 581 individuals — European
(majority European)		 — NR LIVER-BIBLE