Predicted Trait | |
Reported Trait | Venous thromboembolism |
Mapped Trait(s) | venous thromboembolism (EFO_0004286) |
Score Construction | |
PGS Name | PRS_VTE_EUR_GHOUSE |
Development Method | |
Name | PRS-CS |
Parameters | auto |
Variants | |
Original Genome Build | hg19 |
Number of Variants | 1,092,045 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000398 |
Citation (link to publication) | Ghouse J et al. Nat Genet (2023) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | European: 100% 1,064,421 individuals (100%) |
PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
— | [
|
European (Icelandic, American, Danish and Finnish) |
CHB, DBDS, FinnGen, IHCS, deCODE |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM016143 | PSS010047| European Ancestry| 436,440 individuals |
PGP000398 | Ghouse J et al. Nat Genet (2023) |
Reported Trait: Prevalent VTE | OR: 1.51 | AUROC: 0.664 [0.659, 0.669] | — | age, sex, 4 PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS010047 | — | — | [
|
— | European | — | UKB | — |