Polygenic Score (PGS) ID: PGS003332

Predicted Trait
Reported Trait Venous thromboembolism
Mapped Trait(s) venous thromboembolism (EFO_0004286)
Released in PGS Catalog: Jan. 24, 2023
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Score Details

Score Construction
PGS Name PRS_VTE_EUR_GHOUSE
Development Method
Name PRS-CS
Parameters auto
Variants
Original Genome Build hg19
Number of Variants 1,092,045
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000398
Citation (link to publication) Ghouse J et al. Nat Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,064,421 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
[
  • 57,467 cases
  • , 1,006,954 controls
]
European
(Icelandic, American, Danish and Finnish)
CHB, DBDS, FinnGen, IHCS, deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016143 PSS010047|
European Ancestry|
436,440 individuals
PGP000398 |
Ghouse J et al. Nat Genet (2023)
Reported Trait: Prevalent VTE OR: 1.51 AUROC: 0.664 [0.659, 0.669] age, sex, 4 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010047
[
  • 23,723 cases
  • , 412,717 controls
]
European UKB