Polygenic Score (PGS) ID: PGS003333

Predicted Trait
Reported Trait Major Depressive Disorder
Mapped Trait(s) major depressive disorder (MONDO_0002009)
Released in PGS Catalog: Dec. 6, 2022
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Score Details

Score Construction
Development Method
Name PRS-CS-auto
Parameters No p-value threshold for variants
Original Genome Build GRCh37
Number of Variants 1,088,415
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000399
Citation (link to publication) Fang Y et al. Biol Psychiatry (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
807,553 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007342
  • 246,363 cases
  • , 561,190 controls
European 23andMe, PGC, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016144 PSS010048|
European Ancestry|
34,703 individuals
PGP000399 |
Fang Y et al. Biol Psychiatry (2022)
Reported Trait: Major Depressive Disorder Nagelkerke pseudo-R2: 0.022

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010048 phecode 296.22
  • 13,850 cases
  • , 20,853 controls
European MGI