Polygenic Score (PGS) ID: PGS003335

Predicted Trait
Reported Trait Bladder cancer
Mapped Trait(s) urinary bladder carcinoma (MONDO_0004986)
Released in PGS Catalog: Dec. 20, 2022
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Score Details

Score Construction
PGS Name GRS18_BC
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 18
Effect Weight Type ln(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000404
Citation (link to publication) Teleka S et al. Sci Rep (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
36,139 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 29732392
 0 individuals European NR
GWAS Catalog: GCST000231
Europe PMC: 18794855
 36,139 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016166 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma HR: 1.27 [1.15, 1.4] — — Smoking, BMI, education, and physical activity —
PPM016167 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma HR: 1.34 [1.18, 1.52] — — Smoking, BMI, education, and physical activity —
PPM016168 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma HR: 1.19 [1.0, 1.42] — — Smoking, BMI, education, and physical activity —
PPM016169 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma x systolic blood pressure interaction HR: 1.55 [1.14, 2.1] — — Smoking, BMI, physical activity and level of education —
PPM016170 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma x systolic blood pressure interaction HR: 1.59 [1.07, 2.35] — — Smoking, BMI, physical activity and level of education —
PPM016171 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma x systolic blood pressure interaction HR: 1.72 [1.03, 2.87] — — Smoking, BMI, physical activity and level of education —
PPM016172 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma x diastolic blood pressure interaction HR: 1.45 [1.09, 1.92] — — Smoking, BMI, physical activity and level of education —
PPM016173 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma x diastolic blood pressure interaction HR: 1.54 [1.07, 2.22] — — Smoking, BMI, physical activity and level of education —
PPM016174 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma x diastolic blood pressure interaction HR: 1.38 [0.82, 2.31] — — Smoking, BMI, physical activity and level of education —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010054 — —
[
  • 385 cases
  • , 10,191 controls
]
,
100.0 % Male samples
 Mean = 59.0 years European — MDC —