Polygenic Score (PGS) ID: PGS003354

Predicted Trait
Reported Trait Childhood steroid-sensitive nephrotic syndrome
Mapped Trait(s) nephrotic syndrome (EFO_0004255)
Released in PGS Catalog: Dec. 20, 2022
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Score Details

Score Construction
Development Method
Name Genome-wide significant SNPs
Parameters r2>0.8
Original Genome Build NR
Number of Variants 5
Effect Weight Type ln(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000407
Citation (link to publication) Downie ML et al. Pediatr Nephrol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
6,064 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008456
Europe PMC: 31263063
6,064 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016206 PSS010057|
European Ancestry|
597 individuals
PGP000407 |
Downie ML et al. Pediatr Nephrol (2022)
Reported Trait: Non-monogenic idiopathic nephrotic syndrome AUROC: 0.638 [0.543, 0.733]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010057 597 individuals European NR BRIDGE