Polygenic Score (PGS) ID: PGS003384

Predicted Trait
Reported Trait Glioblastoma
Mapped Trait(s) glioblastoma (MONDO_0018177)
Released in PGS Catalog: Jan. 19, 2023
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Score Details

Score Construction
PGS Name best_GBM
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 1×10^-1, r2 < 0.1
Variants
Original Genome Build GRCh37
Number of Variants 910
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000413
Citation (link to publication) Namba S et al. Cancer Res (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 100%
15,094 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006480
Europe PMC: 30152087
15,094 individuals Not reported NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016259 PSS010078|
European Ancestry|
269,806 individuals
PGP000413 |
Namba S et al. Cancer Res (2022)
Reported Trait: glioblastoma AUROC: 0.758 : 0.0216 age, sex, top 20 genetic principal components

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010078 C71, histology was either Giant cell glioblastoma or Glioblastoma (NOS)
[
  • 262 cases
  • , 269,544 controls
]
European
(British)
UKB Controls were samples without any cancer diagnosis or self-reported cancer