Polygenic Score (PGS) ID: PGS003401

Predicted Trait
Reported Trait Triglyceride levels
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Released in PGS Catalog: Jan. 19, 2023
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Score Details

Score Construction
PGS Name TG.PS
Development Method
Name Genome-wide significant SNPs
Parameters r2 < 0.1
Variants
Original Genome Build NR
Number of Variants 108
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000418
Citation (link to publication) Pieri K et al. Int J Cardiol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
237,050 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009149
Europe PMC: 29083408
 237,050 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017030 PSS010100|
European Ancestry|
460,037 individuals
 PGP000418 |
Pieri K et al. Int J Cardiol (2022)
 Reported Trait: Plasma triglyceride concentration β: 0.142 (0.000753) — % change in TG (per SD PGS): 15.2 [15.0, 15.4] — —
PPM017031 PSS010099|
European Ancestry|
6,952 individuals
 PGP000418 |
Pieri K et al. Int J Cardiol (2022)
 Reported Trait: Plasma triglyceride concentration β: 0.122 (0.00495) — % change in TG (per SD PGS): 13.0 [12.0, 14.0] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010100 — — 460,037 individuals,
45.7 % Male samples
 — European — UKB —
PSS010099 — — 6,952 individuals,
43.5 % Male samples
 — European — OBB —