Polygenic Score (PGS) ID: PGS003403

Predicted Trait
Reported Trait LDL cholesterol
Mapped Trait(s) low density lipoprotein cholesterol measurement (EFO_0004611)
Released in PGS Catalog: Jan. 19, 2023
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Score Details

Score Construction
PGS Name PRS28_LDL
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 28
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000420
Citation (link to publication) Trinder M et al. J Am Coll Cardiol (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
94,595 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002220
Europe PMC: 24097068
 94,595 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017041 PSS010102|
European Ancestry|
626 individuals
 PGP000420 |
Trinder M et al. J Am Coll Cardiol (2019)
 Reported Trait: LDL-C levels — — pvalue (High >=80 percentile vs lower <80th percentile): 0.03 — —
PPM017046 PSS010104|
European Ancestry|
89,528 individuals
 PGP000422 |
Vanhoye X et al. Transl Res (2022)
|Ext.		 Reported Trait: LDL-c blood concentration β: 0.18 [0.18, 0.18] AUROC: 0.6233 [0.617, 0.63] R²: 0.1055 Age, BMI, sex, age —
PPM017042 PSS010102|
European Ancestry|
626 individuals
 PGP000420 |
Trinder M et al. J Am Coll Cardiol (2019)
 Reported Trait: Cardiovascular disease events in patients with monogenic familial hypercholesterolemia — — Adjusted Hazard Ratio (aHR; top 20% vs. remaining): 3.06 [1.56, 5.99] age, sex, LDL-C, diabetes mellitus, and hypertension —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010102 — — 626 individuals,
49.4 % Male samples
 Mean = 46.2 years European — BCFH —
PSS010104 — — 89,528 individuals — European — UKB —