Polygenic Score (PGS) ID: PGS003423

Predicted Trait
Reported Trait Ankylosing spondylitis
Mapped Trait(s) ankylosing spondylitis (EFO_0003898)
Released in PGS Catalog: Feb. 8, 2023
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Score Details

Score Construction
PGS Name PRS100_Lassosum
Development Method
Name lassosum
Parameters NR
Original Genome Build NR
Number of Variants 100
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000431
Citation (link to publication) Ko CL et al. J Transl Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
144 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
  • 21 cases
  • , 124 controls
East Asian

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017076 PSS010115|
East Asian Ancestry|
1,298 individuals
PGP000431 |
Ko CL et al. J Transl Med (2022)
Reported Trait: Ankylosing spondylitis AUROC: 0.7754

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 185 cases
  • , 1,112 controls
East Asian