Polygenic Score (PGS) ID: PGS003425

Predicted Trait
Reported Trait Hemoglobin
Mapped Trait(s) hemoglobin measurement (EFO_0004509)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name prscs_hemoglobin
Development Method
Name PRS-CS
Parameters PRS-CS-auto in FinnGen, LD reference panel: European ancestry in 1000 Genomes, HapMap3 SNPs
Variants
Original Genome Build hg38
Number of Variants 1,082,250
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000432
Citation (link to publication) Toivonen J et al. Vox Sanguinis (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
408,112 individuals (100%)
Score Development/Training
European: 100%
260,405 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90002384
Europe PMC: 32888494
 408,112 individuals European UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 260,405 individuals,
44.0 % Male samples
 European
(Finnish)		 FinnGen — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017080 PSS010117|
European Ancestry|
13,780 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Hemoglobin levels in postmenopausal females — — R²: 0.04 — —
PPM017078 PSS010118|
European Ancestry|
21,577 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Hemoglobin levels in males — — R²: 0.07 — —
PPM017079 PSS010116|
European Ancestry|
5,403 individuals
 PGP000432 |
Toivonen J et al. Vox Sanguinis (2023)
 Reported Trait: Hemoglobin levels in postmenopausal females — — R²: 0.06 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010116 — — 5,403 individuals,
0.0 % Male samples
 — European
(British)		 — INTERVAL —
PSS010117 — — 13,780 individuals,
0.0 % Male samples
 — European
(British)		 — INTERVAL —
PSS010118 — — 21,577 individuals,
100.0 % Male samples
 — European
(British)		 — INTERVAL —