Polygenic Score (PGS) ID: PGS003427

Predicted Trait
Reported Trait Left ventricular mass index (LVMI)
Mapped Trait(s) left ventricular mass index (EFO_0009290)
Additional Trait Information Cardiac magnetic resonance-derived LVMI
Released in PGS Catalog: March 24, 2023
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name lvmi
Development Method
Name Pruning and Thresholding (P+T)
Parameters r2=0.3, p=1x10-4
Variants
Original Genome Build GRCh37
Number of Variants 465
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000434
Citation (link to publication) Khurshid S et al. Nat Commun (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 96.8%
Multi-ancestry (excluding European): 1.3%
  • Additional Asian Ancestries
  • Additional Diverse Ancestries
Not Reported: 0.8%
African: 0.6%
Additional Diverse Ancestries: 0.5%
43,230 individuals (100%)
Score Development/Training
European: 96.8%
Multi-ancestry (excluding European): 1.3%
  • Additional Asian Ancestries
  • Additional Diverse Ancestries
Not Reported: 0.8%
African: 0.6%
Additional Diverse Ancestries: 0.5%
43,230 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 198 individuals Other admixed ancestry UKB
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 327 individuals NR UKB
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 41,855 individuals European UKB
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 577 individuals Asian unspecified, Oceanian UKB
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 273 individuals African unspecified UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 41,855 individuals European UKB — — — — —
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 577 individuals Asian unspecified, Oceanian UKB — — — — —
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 273 individuals African unspecified UKB — — — — —
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 198 individuals Other admixed ancestry UKB — — — — —
GWAS Catalog: GCST90244710
Europe PMC: 36944631
 327 individuals NR UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017101 PSS010124|
Multi-ancestry (including European)|
29,354 individuals
 PGP000434 |
Khurshid S et al. Nat Commun (2023)
 Reported Trait: incident implantable cardioverter-defibrillator implant HR: 1.05 — — age, sex, PC 1-5 —
PPM017100 PSS010123|
Multi-ancestry (including European)|
443,326 individuals
 PGP000434 |
Khurshid S et al. Nat Commun (2023)
 Reported Trait: incident implantable cardioverter-defibrillator implant HR: 1.07 — — age, sex, PC 1-5 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010123 — 443,326 individuals,
45.5 % Male samples
 Mean = 57.2 years European, NR 94% European UKB —
PSS010124 — 29,354 individuals,
45.5 % Male samples
 Mean = 55.4 years European, NR 85% European PHB —