Polygenic Score (PGS) ID: PGS003437

Predicted Trait
Reported Trait Thyroid cancer
Mapped Trait(s) thyroid carcinoma (EFO_0002892)
Released in PGS Catalog: March 3, 2023
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Score Details

Score Construction
PGS Name PRS23_TC
Development Method
Name Genome-wide significant SNPs
Parameters r2 < 0.99, MAF ≥ 0.01, P < 5×10-5
Variants
Original Genome Build NR
Number of Variants 23
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000439
Citation (link to publication) Feng X et al. JAMA Netw Open (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 99.4%
Not Reported: 0.6%
776,901 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002102
Europe PMC: 23894154
 1,187 individuals European NR
GWAS Catalog: GCST000335
Europe PMC: 19198613
 37,388 individuals European NR
GWAS Catalog: GCST001382
Europe PMC: 22267200
 27,758 individuals European NR
Europe PMC: 25029422
[
  • 2,260 cases
  • , 2,218 controls
]
 Not reported NR
GWAS Catalog: GCST002873
Europe PMC: 25855579
 900 individuals European NR
GWAS Catalog: GCST004144
Europe PMC: 28195142
 290,551 individuals European NR
GWAS Catalog: GCST90011813
Europe PMC: 32887889
 411,112 individuals European NR
GWAS Catalog: GCST012197
Europe PMC: 33527407
 3,527 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017148 PSS010136|
European Ancestry|
264,956 individuals
 PGP000439 |
Feng X et al. JAMA Netw Open (2022)
 Reported Trait: Incident thyroid cancer x total moderate to vigorous physical activity interaction HR: 0.74 [0.57, 0.97] — — age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax —
PPM017149 PSS010136|
European Ancestry|
264,956 individuals
 PGP000439 |
Feng X et al. JAMA Netw Open (2022)
 Reported Trait: Incident thyroid cancer x smoke intake interaction HR: 0.48 [0.32, 0.72] — — age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax —
PPM017145 PSS010136|
European Ancestry|
264,956 individuals
 PGP000439 |
Feng X et al. JAMA Netw Open (2022)
 Reported Trait: Thyroid cancer HR: 1.95 [1.68, 2.26] AUROC: 0.64 [0.61, 66.0] — age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax —
PPM017147 PSS010136|
European Ancestry|
264,956 individuals
 PGP000439 |
Feng X et al. JAMA Netw Open (2022)
 Reported Trait: Incident thyroid cancer x healthy lifestyle interaction HR: 0.52 [0.37, 0.73] — — age, sex, and genetic composition, townsend deprivation index at recruitment, qualifications and average total household income before tax —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010136 — —
[
  • 423 cases
  • , 264,533 controls
]
 — European — UKB —